Correlations between monocyte immunosuppression and the inflammatory markers in patients with severe acute stroke
10.3760/cma.j.issn.1671-8925.2008.10.025
- VernacularTitle:急性重症脑卒中患者单核细胞免疫抑制与炎性标志物的相关性
- Author:
Dao-Pei ZHANG
1
;
Fu-Ling YAN
;
Yi-Xin ZHU
;
Hai-Qing XU
;
Bao-Yu YUAN
;
Yan YIN
;
Hang-Qing LU
Author Information
1. 东南大学附属中大医院
- Keywords:
Acute stroke;
Human leucocyte antigen-DR;
C-reactive protein;
Fibrinogen
- From:
Chinese Journal of Neuromedicine
2008;7(10):1067-1070
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations between monocyte immunodepression andthe levels of C-reactive protein (CRP) and fibrinogen (Fg) in patients with severe acute stroke. MethodsThis prospective study involved 53 consecutive patients admitted in the neurological intensive care unit(NICU) within 24 h after stroke onset. Blood samples were collected serially on days 1, 2, 4, 6 and 14after stroke to determine monocytic HLA-DR expression using flow cytometry. CRP and Fg weredetected on day 2 after the admission, and Graph_Pad PRISM 4.0 software was used to analyze thecorrelations among the variables. Thirty-nine concurrent patients admitted in the general ward, whocomplained dizziness without magnetic resonance imaging evidence of acute stroke, were enrolled toserve as the control group. Results The levels of CRP and Fg in the stroke group were significantlyhigher than those in the control group (P<0.05). The CRP and Fg levels were both found to inverselycorrelate to monocytic HLA-DR expression at different observational points. The correlations of CRP andFg to HLA-DR expression were the most obvious on day 2 and 4 after admission (r=-0.419, P=0.001;r=-0.434, P=0.001), respectively. Conclusion Immunosuppression of the monocytes in patients withsevere acute stroke is probably associated with the inflammatory reaction after stroke.
