Early mechanical ventilation improves the clinical outcome of the patients with severe brain injury
10.3760/cma.j.issn.1671-8925.2008.09.022
- VernacularTitle:早期机械通气对重型颅脑损伤预后的影响
- Author:
Zhan-Peng LI
1
;
Chun-Wan YANG
;
Cong ZHANG
;
Rui-Ju CHEN
;
Guo-Quan HUANG
Author Information
1. 广东省肇庆市第一人民医院
- Keywords:
Mechanical ventilation;
Craniocerebral injury;
Oxygen saturation
- From:
Chinese Journal of Neuromedicine
2008;7(9):947-949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of early mechanical ventilation on the clinical outcome of the patients with severe brain injury. Methods In 251 patients sustaining severe brain injuries with Glasgow Coma Scores(GCS)of 5 to 8,early mechanical ventilation was administered in 128 patients,with the other 123 patients serving as the control group.The oxygen saturation(SaO2),oxygen pressure(PaO2),carbon dioxide pressure(PaCO2),GCS score,heart rate(HR),andblood pressure (BP)were measured before and after the ventilation in the two groups,and the prognosis of the patients were evaluated.Results Before the treatment,the two groups showed comparable SaO2,PaO2,PaCO2,BP,HR and GCS scores(P>0.05).Compared with the control group,early mechanical ventilation significantly improved the blood gas parameters 24 h and 7 and 14 days after the treatment. SaO2 and PaO2 showed significant increases(P<0.05)and PaCO2 decreased significantly(P<0.05)after early ventilation,which resulted in no significant changes in the HR and BP(P>0.05). Conclusion Early mechanical ventilation can significantly improve the blood gas parameters and the clinical outcome of the patients with severe brain injury.
