Dynamic changes in peripheral blood CD34+ cells and plasma VEGF levels in patients with acute cerebral infarction
10.3760/cma.j.issn.1671-8925.2008.09.017
- VernacularTitle:急性脑梗死患者外周血CD34+细胞与血管内皮细胞生长因子动态变化及其临床意义
- Author:
Xiao-Jian YIN
1
;
Chang-mei FU HUANG
;
Bin ZHAO
Author Information
1. 广东医学院附属医院
- Keywords:
Acute cerebral infarction;
Vascular endothelial growth factor;
CD34+cells
- From:
Chinese Journal of Neuromedicine
2008;7(9):932-934
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes in peripheral blood CD34+cells and plasma levels ofvascular endothelial growth factor(VEGF)in patients with acute cerebral infarction.and explore the roles of CD34+ cells and VEGF in acute cerebral infarcfion. Methods In 40 patients with acute cerebral infarction,the counts of CD34+cells in tlle peripheral blood were measured using flow cytometry on days 3,7,10 and 14 following the onset,with 40 healthy individuals as the control.Plasma levels of VEGF were also measured in these subjects at the same time points using enzyme-linked immunoassay(ELISA). Results Peripheral CD34+ cells increased significantly after the onset of acute cerebral infarction,reaching the peak level on day 10.Plasma VEGF levels also increased significantly in the patients as compared with that in the control subjects,reaching the peak level on days 7to 10.An obvious correlation was noted between the levels of pefipheral blood CD34+cells and VEGF levels in the patients with acute cerebral infarction. Conclusion Increased peripheral VEGF level and CD34+cells folMwing acute cerebral infarction may promote angiogenesis,improve brain tissue hypoxia isehemia,and so play a role in the protection of nerve function.
