Analysis of nerve conduction abnormalities in POEMS syndrome
10.3760/cma.j.issn.1671-8925.2008.08.023
- VernacularTitle:POEMS综合征神经传导异常分析
- Author:
Qiang SHI
1
;
Xu-Sheng HUANG
;
Zhao-Hui CHEN
;
Sheng-Yuan YU
;
Wei-Ping WU
;
Chuan-Qiang PU
Author Information
1. 解放军总医院
- Keywords:
POEMS syndrome;
Electrophysiology
- From:
Chinese Journal of Neuromedicine
2008;7(8):835-837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the electrophysiological features of POEMS syndrome. Methods We retrospectively analyzed the electrophysiological findings of 22 patients of POEMS, and compared their results with those of 22 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Results Compared with the CIDP group, the motor nerve conduction velocity was decreased in the POEMS group, but the difference was not significantstatistically (P>0.05); whereas, distal motor latency (DML) was significantly decreased (P<0.05), and terminal latency index (TLI) was significantly increased (P<0.05). The incidence rate of the nerve conduction block in the POEMS group was lower than that in the CIDP group (P<0.05). Compound muscle action potential (CMAP) of the tibial nerve was decreased significantly in the POEMS group as compared with the CIDP group (P<0.05), whereas CMAP of the median nerve was not significantly different (P>0.05). Abnormal electrophysiology was frequently observed in muscles of lower limbs in the POEMS group, and in comparison of upper limbs, the difference was not significant statistically (P<0.05).Conclusion In POEMS syndrome, slowing of nerve conduction velocity is more predominant in the intermediate segments of the peripheral nerve, and conduction block is rare. Abnormal nerve conduction may be correlated with limbs.
