Therapeutic effect of botulinum toxin type A on upper extremity spasticity after stroke

VernacularTitle:A型肉毒毒素治疗脑卒中后上肢肌痉挛的疗效分析
Author: Ling MENG ¹ ; Geng-Ting LIN ; Xing-Zhou TANG
Author Information

1. 解放军第117医院
Keywords: BTX-A; Cerebral infarction; Upper extremity spasticity
From: Chinese Journal of Neuromedicine 2008;7(7):740-742
CountryChina
Language:Chinese
Abstract: Objective To observe the therapeutic effect ofbotulinum toxin type A (BTX-A) on spasticity of the upper extremity after stroke. Methods Fifty-four patients with upper extremity spasticity after stroke were randomly divided into treatment group and control group. The patients in treatment group were treated with BTX-A and rehabilitation training, while those in control group only with rehabilitation training. The efficacy was assessed with Modified Ashwonh Scale, Fugi-Meyer Assessment and Bartbel index before and 2, 4 and 12 weeks after treatment. Results The Ashworth scale score in treatment group was reduced significantly as compared with that in control group after 2- and 4-week treatment (P<0.01). And there was significant difference in FugI-Meyer Assessment and Barthel index between treatment group and control group after 4- and 12-week treatment (P<0.01). Conclusion The local injection of BTX-A for the muscle spasticity after stroke is effective and safe, and its combination with rehabilitation training can improve rapidly Fugl-Meyer scores and activities of daily living of patients.