Clinical significances of plasma Fbg and D-dimer tn acute stage for the patients with severe head injury
10.3760/cma.j.issn.1671-8925.2008.07.020
- VernacularTitle:重型颅脑损伤急性期血浆纤维蛋白原和D-二聚体动态改变的临床意义
- Author:
Gang LI
1
;
Bi-Lan DENG
;
Xing YU
Author Information
1. 海口市人民医院
- Keywords:
Craniol cerebratrauma;
Fbg;
D-dimer,Coagulation Hyperfibrinolysis
- From:
Chinese Journal of Neuromedicine
2008;7(7):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the dynamic change of plasma fibrinogen (Fbg) and D-dimer within 48 h in blood samples from the patients with simple severe head injury, and explore the correlation of plasma Fbg and D-dimer levels with the patient's prognosis. Methods In 33 patients with simplese vere head injury, we obtained the blood samples from the artery (A), vein (V) and jugular vein (JV) at different time points (post injury 4, 8, 16, 24, 36 and 48 h) and detected the plasma Fbg and D-dimer levels, respectively. The data were statistically analyzed by SPSS ! 1.5. Results Plasma Fbg was higher than the normal value at 4 h after head injury, and then it was decreased obviously and lower than the normal value at 16 h, and since 24 h it was increased to the normal value. The rising of Fbg was slower in jugular vein than in artery and peripheral vein after 24 h (P<0.05). D-dimer was increased at 4 h after injury, and gradually decreased with the time going on, but the level retained over the normal value until 48 h. In the comparison between the patients with bad prognosis and the ones with satisfactory prognosis, the means of plasma Fbg and D-dimer had significant difference at the same time point (P< 0.05). Conclusions Head injury can result in coagulation disorder, which presents Fbg consumption and decrease and its degradation product D-dimer increase obviously. The changes indicate hypercoagulahale state and secondary hyperfibrinolysis after head trauma. The coagulopathy can be an indicator for judging the severity and prognosis of head injury.
