Alterations of metabotropic glutamate receptors in thalamic reticular nuclei of rats after diffuse brain injury

VernacularTitle:弥漫性脑损伤大鼠丘脑网状核代谢性谷氨酸受体变化及意义
Author: Fei FEI ¹ ; Lei ZHANG ; Bing LI
Author Information

1. 第四军医大学
Keywords: Metabotropic glutamate receptors; Thalamic reticular nucleus; Diffuse braininjury
From: Chinese Journal of Neuromedicine 2008;7(7):695-697
CountryChina
Language:Chinese
Abstract: Objective To study the alterations of metabotropic glutamate receptors la (mGluRla) in thalamic reticular nuclei (TRN) of rat brains after diffuse brain injury (DBI) so as to probe into the expression and significance ofmGluRs in DBI. Methods A total of 45 SD male rats weighing 280-320 g were randomized into three groups: normal (untreated), sham-operated (fixed, cut in scalp) and DBI groups (n=15 each group). At the 6, 12, 24 h after modeling, the brain TRN were examined for pathological changes under light microscope. Expressions of mGluRla were detected by immunohistochemical staining of PAP. Results Compared with the control and sham-operated groups, the expressions of mGluRla were increased significantly with the time going on, especially at 12 h, and they were decreased a little at 24 h, but still higher in DBI group, compared with the other 2 groups, the difference was ststically significant (P=0.000). Conclusion The up-regulation of mGluRla in TRN may play an important role in neuronal injury after DBI in rats.