Variant distribution of voltage-gated sodium channel type Ⅰ on different types of neurons in rat hippocampus

VernacularTitle:Ⅰ型电压门控钠离子通道蛋白在大鼠海马区不同类型神经元上的表达差异
Author: Jian-Lei ZHANG ¹ ; Wei-Wen SUN ; Yue-Sheng LONG ; Tao SU ; Hao-Hui CHANG ; Wei-Ping LIAO
Author Information

1. 广州医学院附属第二医院
Keywords: Hippocampus; Neuron; Voltage-gated,type Ⅰ; Sodium channel
From: Chinese Journal of Neuromedicine 2008;7(7):674-676
CountryChina
Language:Chinese
Abstract: Objective To investigate the variant distribution of voltage-gated sodium channel type Ⅰ (Nav1.1) on the different types of neurons in rat hippocampus. Methods In brain tissue sections from adult SD rats, the expression of Nav1.1 on the different types of neurons in rat hippocampus was detected and observed by immunohistochemistry (DAB staining) and laser confocal microscopy. Results Nav1.1 protein was expressed weakly on the soma of pyramidal cells and granular cells of the dentate gyrus, while strongly expressed on the scattered interneurons.Conclusions In the hippocampus of SD rats, the expression of Nav 1.1 protein on interneurons was strong, but weak on the projection neurons (pyramidal cells and granular cells of the dentate gyms). It can be inferred that on different types of neurons, different subtypes of sodium channels are predominately expressed.