Clinical effect of MRI guided stereotactic radiofrequency lesion in patients with intractable schizophrenia
10.3760/cma.j.issn.1671-8925.2008.06.021
- VernacularTitle:MRI定向下核团毁损术治疗难治性精神分裂症
- Author:
Yong-Xin CHEN
1
;
Bo-Min SUN
;
Shi-Kun ZHAN
;
Hai-Yin ZHANG
;
Yong-Chao LI
Author Information
1. 解放军第85医院
- Keywords:
Stereotactic;
Schizophrenia;
Radiofrequency lesion;
MRI guided
- From:
Chinese Journal of Neuromedicine
2008;7(6):624-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect and complications of MRI guided stereotactic radiofrequency lesion in patients with intractable schizophrenia. Methods Thirty-eight cases of intractable schizophrenia underwent MRI guided stereotactic stereotactic radiofrequency lesion for single target or combined target. According to 1990 standards from National Psychosurgery Cooperation, the therapeutic outcome was assessed 6 months after operation. In addition, pre-and post-operative brief psychiatric reacting scale (BPRS) scores were got by psychiatrists for evaluating the curative effect. Results Six months after operation, 8 cases were free from symptoms, 15 cases were significantly improved, 12 improved a little and 3 had no improvement. The effective rate was 92.1%. 15cases had mild transient post-operative complications, and all recovered within 2 weeks. Psychiatric evaluations of BPRS demonstrated that there were significant decreases in total score and factor scores of anxiety-depression, lacking-activity, disturbance, activation and hostile-suspiciousness after operation (P<0.05). Conclusions MRI guided stereotactic radiofrequsency lesion is accurate, safe and effective for intractable schizophrenia.
