Evaluation of brain tolerability with SPECT perfusion imaging during temporary internal carotid artery occlusion
10.3760/cma.j.issn.1671-8925.2008.06.017
- VernacularTitle:应用单光子发射计算机断层扫描脑血流灌注显像评价颈内动脉球囊闭塞试验后大脑耐受性
- Author:
Dan LIU
1
;
Ren-Ling ZHANG
;
Meng LI
Author Information
1. 首都医科大学宣武医院
- Keywords:
Balloon occlusion;
Cerebral blood flow;
Cerebral perfusion;
Tomography,emission-computed;
Single-photon
- From:
Chinese Journal of Neuromedicine
2008;7(6):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the usefulness of brain single photon emission computed tomography (SPECT) during temporary carotid balloon occlusion testing. Methods Temporary balloon occlusion testing was performed on 31 patients with internal carotid artery aneurysms. During the balloon occlusion, 99mTc-ethylcysteinate dimer (ECD) was injected intravenously about 5 rain before balloon deflation, followed by SPECT data acquisition. SPECT images were visually evaluated, and the severity of hypoperfusion on the occluded side was classified using 4 grades (normal, mild, moderate, and severe). The count ratio of the occluded side to the contra-lateral side (L/N ratio) was also analyzed. Results SPECT after temporary occlusion showed mild, moderate or severe hypoperfusion in 24 patients, whereas neurologic deterioration was observed in only 4 patients. The L/N ratios were 0.98±0.03in normal perfusion (7 patients), 0.89+0.03 in mild hypoperfusion(11 patients), 0.81±0.03 in moderate hypoperfusion(7 patients), and 0.66±0.04 in severe hypoperfusion(6 patients)(P=0.000). Conclusion SPECT is a useful, convenient, sensitive way to detect cerebral hypoperfusion during carotid occlusion.