Primary research on accelerated healing of experimental aneurysm embolized by fibrin glue-fibroblast compound

VernacularTitle:成纤维细胞-纤维蛋白胶复合物促进动脉瘤闭塞的初步实验研究
Author: Hai-Dong WANG ¹ ; Da-Shang LING ; Yong-Hui MA ; Guo-Wei TAN ; Zhan-Xiang WANG
Author Information

1. 福建医科大学附属厦门第一医院
Keywords: Fibrin glue-fibroblast compound; Embolization,therapeutic; Intracranial aneurysm
From: Chinese Journal of Neuromedicine 2008;7(6):589-591,595
CountryChina
Language:Chinese
Abstract: Objective To probe the feasibility of the aneurysm embolization with fibrin glue-fibroblast compound by carotid artery angiography and pathological examination in New Zealand rabbit model. Methods The primarily cultured fibroblast cells were obtained by tissue engineering technique in vitro, and the fibroblast bank was established. Then fibroblast cells were cultured in human fibrin glue. Aneurysms of 12 rabbits were embolized directly by fibrin glue-fibroblast compound in 6 cases or fibrin glue in the other 6 cases. DSA angiography was performed 2 and 4 weeks after embolization, and pathological examination was conducted 4 weeks after embolization. Results Fibroblasts grew in fibrin glue in vitro. Embolization efficacy of fibrin glue-fibroblast compound was obviously superior to that of fibrin glue only. Conclusions Fibrin glue-fibroblast compound can be considered as candidate material for aneurysm embolization.