Expressions of PCNA, Ki-67 and Mitosin/CENP-F proteins in human gliomas
10.3760/cma.j.issn.1671-8925.2008.06.004
- VernacularTitle:人脑胶质瘤中PCNA、Ki-67和Mitosin/CENP-F的表达研究
- Author:
Jin XIAO
1
;
Jing-Hai WAN
;
Chang-Yuan LI
;
Chun-Guo FENG
;
Zhi-Fan LI
;
Xian-Xiang WANG
Author Information
1. 安徽医科大学附属第一医院
- Keywords:
Glioma;
Centromeric protein F;
Ki-67;
PCNA;
Immunohistochemistry
- From:
Chinese Journal of Neuromedicine
2008;7(6):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of PCNA, Ki-67 and Mitosin/CENP-F and the relationship with biological features of human gliomas. Methods The Labeling Index (LI) of PCNA, Ki-67 and Mitosin/CENP-F proteins was detected by immunohistochemistry in 70 cases of human glioma of various pathological types and grades and 24 cases of non-tumor brain tissue samples. Results LI values of PCNA, Ki-67 and Mitosin/CENP-F in 70 cases of glioma were (44.02±29.37)%, (17.01±17.68)% and (36.80±27.23)%, respectively. In non-tumor brain tissue samples, the expression of Ki-67 was negative, and LI values of PCNA and Mitosin/CENP-F were (12.11±19.81)% and (9.06±8.27)%. There were statistically significant differences between glioma and non-tumor brain tissue samples (P<0.01). In addition, the correlation between the increasing grade and various histologic types and PCNA, Ki-67 and Mitosin/CENP-F LI values were statistically significant (P<0.05). However, no correlation was detected between the age and sex of the patiets and any one of three markers. Conclusion PCNA, Ki-67 and Mitosin/CENP-F, three tumor markers can be used to evaluate the tumor grade and to asses the malignancy in human gliomas.
