Clinical and MRI diagnosis of brain multiple sclerosis
10.3760/cma.j.issn.1671-8925.2008.05.013
- VernacularTitle:颅脑多发性硬化的临床及MRI诊断
- Author:
Hua-Wang WU
1
;
Guan-Xun CHENG
;
Jing ZHANG
;
Li-Ning LIANG
Author Information
1. 南方医科大学南方医院
- Keywords:
Multiple sclerosis;
Magnetic resonance imaging
- From:
Chinese Journal of Neuromedicine
2008;7(5):479-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical and MRI features of multiple sclerosis and to get a better understanding and diagnosing level of brain multiple sclerosis. Methods Twenty patients of brain multiple sclerosis were evaluated retrospectively with regard to clinical data, lesion location,shapes, MR signal and enhancement patterns, as well as the changes of corpus callosum. Results Multiple sclerosis often occurred in young and middle-aged women with acute and subacute onset. The initial symptoms included visual disturbance, acrognosis or motor disturbance. The vision-evoked potential was abnormal in most patients. Lesions were found in 18 patients by MRI scanning, the sensitivity of MKI being 90% (18/20). The distribution of lesions were observed most frequently at the two sides of periventricle, cortical and juxtacortical of frontal lobe and centrum semiovale. The shape of lesions were mostly round or ovate with different sizes. Two typical manifestations of multiple sclerosis were "right-angle demyelination sign" and "dirty-appearing white matter ". The lesions showed as isointensive or hypointensive on T1WI, hyperintensive on T2WI and Flair sequences. The lesions showed as nodular enhancement, ringlike enhancement, arc enhancement or nonenhancment on T1 enhancement scanning. Conclusions MRI appearances of multiple sclerosis have some characteristics. MRI is helpful to diagnosis and differential diagnosis of multiple sclerosis, and also the most sensitive imaging method for multiple sclerosis.
