Coexpression of CyclinD1 and PCNA in gliomas and its correlation with glioma pathological grades and prognosis

VernacularTitle:人脑胶质瘤中CyclinD1和PCNA联合检测与肿瘤分级及患者预后相关性研究
Author: Chong-Xiao LIU ¹ ; Wei SHI ; Lian-Wei KE ; Jian-Qiang QU ; Fang-Ru WANG ; Bin BAI ; Kang-Min WANG
Author Information

1. 西安交通大学医学院附属第二医院
Keywords: Glioma; PCNA; CyclinD1; Pathological grade; Prognosis
From: Chinese Journal of Neuromedicine 2008;7(5):437-439
CountryChina
Language:Chinese
Abstract: Objective To investigate the coexpression of CyclinD1 and proliferating cell nuclear antigen (PCNA) in gliomas and find out its correlation with glioma pathological grades and prognosis. Methods SP immunohistochemical method was used to detect the coexpression of CyclinD1 and PCNA in 63 patients with glioma. All cases were followed up. The labeling index (LI) of CyclinD1 or/and PCNA was compared in different glioma pathological grades and survival periods.Results The LI of CyclinD1 and PCNA was increased with the increase of glioma grades, and there were significant differences among different glioma grades (P＜0.05). While the LI of CyclinD1 and PCNA was decreased with the prolonging of survival period, and there were significant differences among different survival periods (P＜0.05). Conclusions The LI of CyclinD1 and PCNA is more accurate than the one of CyclinD1 or PCNA alone when used for evaluating glioma grades and prognosis,so it can be a diagnostic index for the evaluation of glioma grades and prognosis.