Comparison between pathologic, clinical and MRI findings of demyelinating pseudotumor in brain
10.3760/cma.j.issn.1671-8925.2008.04.015
- VernacularTitle:脑内脱髓鞘假瘤病理、临床与磁共振成像对照分析
- Author:
Shou-Qiang JIA
1
;
Yong-Xiu WANG
;
Qing-Guo LI
;
Fang-Yu SONG
;
Hai-Feng LI
Author Information
1. 山东省莱芜市人民医院
- Keywords:
Demyelinating pseudotumor;
Pathology;
Clinic;
MRI
- From:
Chinese Journal of Neuromedicine
2008;7(4):380-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the MRI findings and study the correlations between pathologic, clinical and MRI findings of demyelinating pseudotumor in brain. Methods Pathologic,clinical and MRI findings in 8 cases proved pathologically with demyelinating pseudotumor in brain were retrospectively analyzed. Results The clinical manifestations comprised mostly dyskinesia and/or limb sensory disability, as well as epilepsy in few cases. MRI showed a single focal lesion mainly invading subcortical white matter in every case, and most lesions were showed round or nearly round with clear boundary, homogenous low signal on T1WI and high signal on T2WI, and marked enhancement. Pathological examination showed demyelinating, perivascular inflammatory infiltration consisting predominantly of lymphocytes, and glial cell proliferation. Conclusions MRI can well mirror the pathological and clinical changes of demyelinating pseudotumor in brain, so MRI plays an important role in its diagnosis. It is easy to make a differential diagnosis between glioma and supratentorial demyelinating pseudotumor, but it is difficult for those lesions in cerebellum. For such cases, both clinical and MRI diagnosis are necessary. Trial treatment of corticoids or even biopsy is available for those cases that are difficult to diagnose by clinical and MRI methods.
