Clinical and radiologic study in Marchiafava-Bignami disease
10.3760/cma.j.issn.1671-8925.2008.03.024
- VernacularTitle:Marchiafava-Bignami病的临床及影像学研究
- Author:
Bo GAO
1
;
Cui L(U)
;
Gui-Quan SHEN
;
Xue-Jian WANG
;
Feng-Li LIU
;
Xu-Qing SU
Author Information
1. 山东省烟台市毓璜顶医院
- Keywords:
Marchiafava-Bignami disease;
Magnetic resonance imaging;
Diffusion magnetic resonance imaging
- From:
Chinese Journal of Neuromedicine
2008;7(3):301-303,310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clillicoradiologic characteristics of MarchiafavaBignami disease (MBD). Methods The clinical and neuroimaging findings, including lesion morphorogy, distribution, signal intensity/density in 7 MBD patients were retmspectiVely analyzed.Diffusion-weighted imaging(DWI)was performed in 5 cases.Of the 7 cases,4 underwent both CT and MRI,2 only CT and 1 MRI. Results with extensive iso-or slightly hypo-intensity on T1-weighted images and hyper-intensity on T2-weighted images, 5 patients were manifested as acute onset, in which white matter (WM) was symmetrically involved in bilateral periventricular and frontal subconical regions. Punctate or linear hypo-intensity on FLAIR images was found in the atrophied corpus callosum in 1 case presented as chronic type, with scattered patchy hyper-intensity in periventricular WM and frontal subcortical WM. DWI showed markedly hyper-intensity with diffusion restriction in 2 cases in acute phase with apparent diffusion coefficient(ADC)values(0.52～0.55)×10-3 mm2/s.Brain atrophy was found in all the 7 patients. Conclusions The MRI features of MBD are characteristic and may be associated with the clinical spectrum and prognosis.
