Advances in the mechanisms of keratoconus secondary to vernal keratoconjunctivitis
10.3980/j.issn.1672-5123.2024.7.14
- VernacularTitle:春季角结膜炎发生圆锥角膜的机制研究进展
- Author:
Qiting LUO
1
;
Chaoran ZHANG
1
Author Information
1. Shanghai Medical College of Fudan University, Shanghai 200032, China
- Publication Type:Journal Article
- Keywords:
vernal keratoconjunctivitis;
keratoconus;
cytokines;
hypersensitivity;
inflammatory reaction;
mechanism
- From:
International Eye Science
2024;24(7):1084-1087
- CountryChina
- Language:Chinese
-
Abstract:
Vernal keratoconjunctivitis is an allergic ocular surface disease mostly present with recurrent chronic inflammation, which usually affects children and adolescents and possibly results in corneal complications such as keratoconus. Keratoconus is a corneal disease characterized by a local cone-like corneal deformation. Previous studies have respectively put forward pathological mechanisms of vernal keratoconjunctivitis and keratoconus and the progressive risk factors, among which we find there's mutual mechanisms as well as cytokines' expression, including type I and IV hypersensitivity, inflammatory reaction, enzymatic changes, oxidative stress and mechanical injury. This review aims at summarizing the possible intrinsic mechanisms and cytokines exacerbating vernal keratoconjunctivitis patients corneas to keratoconus, so as to provide reference for the prevention and management in keratoconus caused by vernal keratoconjunctivitis.
