Research progress of extracellular matrix in age-related macular degeneration
10.3980/j.issn.1672-5123.2024.7.12
- VernacularTitle:细胞外基质在年龄相关性黄斑变性中的研究进展
- Author:
Ning YANG
1
;
Xinrong XU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
extracellular matrix;
choroidal neovascularization;
subretinal fibrosis;
retinal pigment epithelium cell;
fibroblast;
microglia;
macrophage
- From:
International Eye Science
2024;24(7):1073-1077
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(ARMD)is the leading cause of blindness in the elderly. Studies have shown that the regulation disorder of extracellular matrix(ECM)is one of the important characteristics of ARMD, and its damage can be sustained throughout the disease course. Additionally, various cell types participate in the formation and abnormal deposition of ECM under the control of multiple signals. Subsequently, they transmit signals that regulate adhesion, migration, proliferation, apoptosis, survival or differentiation, which lead to the destruction of the retinal and choroidal microenvironment, immune dysfunction, infiltrative inflammatory cell differentiation, neovascularization and epithelial mesenchymal transformation, and ultimately lead to subretinal fibrosis, scarring and severe visual impairment in advanced ARMD. Therefore, increasing attention has been paid to the role of ECM in ARMD in recent years. This article reviews the relationship between retinal ECM and ARMD and the role between ECM and various types of cells in ARMD, hoping to provide guidance for the research direction of ARMD treatment.
