Recalcitrant gram-positive bacterial keratitis treated with intrastromal levofloxacin 1.5% ophthalmic solution: A case report and review of literature
- Author:
Bobbie Marie M. Santos
1
;
Josept Mari S. Poblete
1
;
George Michael N. Sosuan
1
;
Pablito F. Sandoval Jr.
1
;
Billie Jean T. Cordero
1
;
David Ammiel R. Tirol V
1
;
Ruben Lim Bon Siong
1
,
2
Author Information
- Publication Type:Journal Article
- Keywords: Intrastromal injection; Bacterial keratitis; Recalcitrant keratitis
- MeSH: Fluoroquinolones; Levofloxacin
- From: Philippine Journal of Ophthalmology 2024;49(1):54-60
- CountryPhilippines
- Language:English
-
Abstract:
Objective:This paper demonstrated the effectiveness of intrastromal injection of levofloxacin 1.5%
ophthalmic solution in the management of recalcitrant Gram-positive bacterial keratitis.
Methods:This is a report on two cases of recalcitrant bacterial keratitis encountered at the External Diseases and Cornea Clinic of the Department of Ophthalmology and Visual Sciences at the Philippine General Hospital.
Results:Two middle-aged females presented with bacterial keratitis unresponsive to previous antibiotic treatment with impending corneal perforation. The Gram stain of the corneal scraping in the first case revealed Gram-positive cocci, while the second case showed encapsulated Gram-positive bacilli and encapsulated Grampositive cocci in chains. In both cases, repeated intrastromal injections of levofloxacin 1.5% in addition to increasing the frequency of topical levofloxacin 1.5% resulted in marked improvement in visual acuity and resolution of deep stromal infiltrates and hypopyon.
Conclusion:These cases highlighted the utility of intrastromal levofloxacin 1.5% ophthalmic solution in the management of recalcitrant Gram-positive bacterial keratitis. - Full text:2024062709123222452pjo 9.pdf
