Role of T-cell immunoglobulin and mucin domain-containing molecule 3 in the development and progression of liver diseases
- VernacularTitle:T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用
- Author:
Shiyu YUAN
1
;
Huanhuan YANG
;
Yingmei TANG
Author Information
- Keywords: Liver Diseases; T-Cell Immunoglobulin and Mucin Domain-containing Molecule-3; Diagnosis
- From: Journal of Clinical Hepatology 2024;40(6):1275-1280
- CountryChina
- Language:Chinese
- Abstract: T-cell immunoglobulin and mucin domain-containing molecule-3(Tim-3)is a member of the Tim family and has been a research hotspot in recent years.As a negative regulatory factor,Tim-3 exerts different effects by binding to different ligands.Tim-3 is expressed in various types of immune cells,such as natural killer cells,dendritic cells,and monocytes,and Tim-3 has a regulatory effect on the functions of these immune cells.In recent years,a large number of studies have shown that Tim-3 is closely associated with the development and progression of liver diseases.This article reviews the studies on the role and mechanism of Tim-3 in different liver diseases and cells in recent years,in order to provide richer perspectives and ideas for the clinical diagnosis and treatment of liver diseases.
