Role of T-cell immunoglobulin and mucin domain-containing molecule 3 in the development and progression of liver diseases
- VernacularTitle:T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用
- Author:
Shiyu YUAN
1
;
Huanhuan YANG
1
;
Yingmei TANG
1
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; TCell Immunoglobulin and Mucin Domaincontaining Molecule-3; Diagnosis
- From: Journal of Clinical Hepatology 2024;40(6):1275-1280
- CountryChina
- Language:Chinese
- Abstract: T-cell immunoglobulin and mucin domain-containing molecule-3 （Tim-3） is a member of the Tim family and has been a research hotspot in recent years. As a negative regulatory factor， Tim-3 exerts different effects by binding to different ligands. Tim-3 is expressed in various types of immune cells， such as natural killer cells， dendritic cells， and monocytes， and Tim-3 has a regulatory effect on the functions of these immune cells. In recent years， a large number of studies have shown that Tim-3 is closely associated with the development and progression of liver diseases. This article reviews the studies on the role and mechanism of Tim-3 in different liver diseases and cells in recent years， in order to provide richer perspectives and ideas for the clinical diagnosis and treatment of liver diseases.
