Association between hypertension and the risk of gallstone disease

Wenqian YU; Linjun Xie; Shiyi LI; Yanmei Lou; Guoheng Jiang; Hongyu LI; Zitong Yan; Xuan Bai; Jing Luo; Chi Zhang; Guangcan LI; Xuefeng Shan; Xin Wang

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Association between hypertension and the risk of gallstone disease

VernacularTitle:高血压与胆石症风险的关联性研究
Author: Wenqian YU ¹ ; Linjun XIE ¹ ; Shiyi LI ¹ ; Yanmei LOU ² ; Guoheng JIANG ¹ ; Hongyu LI ¹ ; Zitong YAN ¹ ; Xuan BAI ³ ; Jing LUO ⁴ ; Chi ZHANG ⁵ ; Guangcan LI ⁶ ; Xuefeng SHAN ⁷ ; Xin WANG ¹
Author Information

1. Department of Epidemiology and biostatistics， West China School of Public Health and West China Fourth Hospital， Sichuan University， Chengdu 610041， China
2. Health Management Center， Beijing Xiaotangshan Hospital， Beijing 102211， China
3. School of Public Health， Harbin Medical University， Harbin 150081， China
4. School of Public Health， Chengdu University of Traditional Chinese Medicine， Chengdu 611137， China
5. Department of Prevention， Tianjin Medical University Cancer Institute and Hospital， Tianjin 300060， China
6. Department of Pharmacy， The People’s Hospital of Kaizhou District， Chongqing 405400， China
7. Department of Pharmacy， Bishan Hospital of Chongqing， Chongqing 402760， China
Publication Type:Journal Article
Keywords: Cholelithiasis; Hypertension; Cross-Sectional Studies
From: Journal of Clinical Hepatology 2024;40(6):1215-1225
CountryChina
Language:Chinese
Abstract: ObjectiveThis article aims to investigate the association between hypertension and the risk of GSD by conducting a national multicenter study， a systematic review， and a meta-analysis. MethodsThe study was conducted in three stages. In the first stage， subjects were recruited for health examination in four hospitals in Chengdu， Tianjin， Beijing， and Chongqing， China， from 2015 to 2020， and the multivariate logistic regression analysis was used to investigate the association between hypertension and the risk of GSD in each center. In the second stage， Embase， PubMed， Wanfang Data， VIP， and CNKI databases were searched for related studies published up to May 2021， and a meta-analysis was conducted to further verify such association. In the third stage， the random effects model was used for pooled analysis of the results of the multicenter cross-sectional study and the findings of previous literature. ResultsA total of 633 948 participants were enrolled in the cross-sectional study， and the prevalence rate of GSD was 7.844%. The multivariate logistic regression analysis showed that hypertension was positively associated with the risk of GSD（P<0.05）. Subgroup analysis showed that there was no significant difference in the association between hypertension and GSD between individuals with different sexes， ages， and subtypes of GSD. A total of 80 articles were included in the systematic review and the meta-analysis， and the results showed that the risk of GSD was increased by 1.022 times for every 10 mmHg increase in diastolic pressure and 1.014 times for every 10 mmHg increase in systolic pressure. ConclusionHypertension significantly increases the risk of GSD， and the findings of this study will provide a basis for the etiology of GSD and the identification of high-risk groups.