The association of serum level of interleukin⁃18 with structural progression in knee osteoarthritis
10.19405/j.cnki.issn1000-1492.2023.11.003
- Author:
Pingping Liu
1
;
Junxian Zhou
1
;
Jianhua Xu
1
;
Shuang Zheng
1
;
Jiale Ren
1
;
Changhai Ding
2
,
3
;
Kang Wang
1
Author Information
1. Dept of Rheumatology and Immunology, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
2. Dept of Rheumatology and Immunology, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
3. Clinical Research Centre , Zhujiang Hospital , Southern Medical University, Guangzhou 510280
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
interleukin⁃18;
cartilage defect;
bone marrow lesion;
matrix metalloproteinase
- From:
Acta Universitatis Medicinalis Anhui
2023;58(11):1819-1823
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the cross⁃sectional associations of serum interleukin( IL) Ⅳ18 with cartilage volume , cartilage defects , bone marrow lesions ( BML) and biomarkers of cartilage degradation in patients with
knee osteoarthritis (OA) , and to provide new ideas and new methods for clinical diagnosis and treatment.
Methods:The study included 151 patients with knee OA , a general questionnaire survey was conducted , and the knee strucral was photographed by magnetic resonance imaging (MRI) . The cartilage volume was measured by OsiriX software in 3D⁃FLASH sequence , and cartilage defect and BML were determined in T2⁃weighted sequence. Serum IL-18 and matrix metalloproteinase ( MMP) Ⅳ3 , 13 levels were measured by enzyme⁃linked immunosorbent assay(ELISA) . SPSS software was used for statistical analysis.
Results :In multivariable analyses , serum IL⁃18 level
was consistent at divided part of joint (femorotibial joint and the patella femoral joint , all P < 0. 05) . Serum IL⁃18 level was positively associated with cartilage defect and BML at media femorotibial area (all P < 0. 01) . Serum IL⁃18 level was positively associated with MMP⁃3 (β = 0. 31 , 95% CI:0. 001 - 0. 010) and MMP⁃13 (β = 0. 86 , 95% CI:0. 08 - 0. 10 , all P < 0. 01) .
CI:0. 08 - 0. 10 , all P < 0. 01) . Conclusion Serum IL⁃18 level is negatively associated with cartilage volume and:Serum IL⁃18 level is negatively associated with cartilage volume and positively associated with cartilage defect , BML , MMP⁃3 and MMP⁃13 , suggesting IL⁃18 may play a significant role duce the injury of article cartilage in patients with knee OA and delay the progression of disease.
- Full text:2024062617303795164血清IL-18与膝骨关节炎关节结构改变相关性研究_刘娉娉.pdf
