Prognostic value of m6 A “reader” YTHDF1 in OSCC
10.19405/j.cnki.issn1000-1492.2024.01.022
- Author:
Song Yang
1
;
Jiawei He
1
;
Na Lv
1
;
Yun Gao
2
;
Bin Sun
2
Author Information
1. Medical School of Shihezi University，Shihezi 832000
2. Dept of Oral and Maxillofacial Surgery，The First Affiliated Hospital of Shihezi University，Shihezi 832000
- Publication Type:Journal Article
- Keywords:
OSCC;
m6 A;
YTHDF1;
Western blot;
prognosis
- From:
Acta Universitatis Medicinalis Anhui
2024;59(1):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To investigate the correlation between the expression level of YTHDF1 in oral squamous cell carcinoma ( OSCC) and clinicopathologic features and its potential prognostic value．
Methods :The expression of YTHDF1 in 132 OSCC tissues and 66 paracancerous tissues was detected by immunohistochemistry (IHC) ，and the expression of YTHDF1 protein in OSCC cell lines was detected by Western blot．The correlation between YTHDF1 and clinicopathological features was analyzed by chi-square test．Kaplan-Meier and Cox factors were used to analyze the factors affecting the survival time of the patients and draw the survival curves of the YTHDF1 gene to evaluate its potential clinical significance.
Results :The expression of YTHDF1 in OSCC tissues was higher than that in para- cancerous tissues (P＜0. 001) ，and the expression of YTHDF1 protein increased in OSCC cell lines compared with normal oral epithelial keratinocytes (P ＜0. 001) ．The expression of YTHDF1 was correlated with the TNM stage and T stage of patients with OSCC (P＜0. 05) ，and the patients with high expression of YTHDF1 had a shorter sur- vival time compared with those with low expression (P ＜0. 001) ．
Conclusion : High expression of YTHDF1 may be associated with poor patient prognosis and YTHDF1 may be able to serve as a target for OSCC treatment.
- Full text:2024062509054829770m~6A“阅读器”YTHDF1在OSCC中的预后价值_杨松.pdf
