Research Progress of Anti-cancer Strategies Based on ERK1/2 Post-translational Modification and Spatial Regulation
10.3971/j.issn.1000-8578.2024.23.1332
- VernacularTitle:基于ERK1/2翻译后修饰调控及空间性调节的抗癌策略研究进展
- Author:
Ting GUO
1
;
Mengyu SHANG
;
Yin GUO
;
Weiren HUANG
Author Information
1. 530200 南宁,广西中医药大学研究生院
- Keywords:
ERK1/2;
Tumor;
Targeted therapy;
Post-translational modifications;
Dimerization;
Small mole-cule inhibitor
- From:
Cancer Research on Prevention and Treatment
2024;51(6):475-483
- CountryChina
- Language:Chinese
-
Abstract:
ERK1/2 is a key protein that mediates cell signal transduction,and it is involved in regulating biological processes such as chromatin remodeling,nuclear disintegration,proliferation,survival,metabolism,and cell migration and differentiation.Its overactivation is closely related to the occurrence and progression of cancer,and the mechanism is manifested as the overactivation of ERK1/2 by gene mutations of upstream pathway molecules or regulators and the reactivation of ERK1/2 after inhibition against the above targets.ERK1/2 is a potentially valuable target.In this review,the mechanism of post-translational modification and spatial regulation of ERK1/2 and the application status of corresponding small-molecule inhibitors were discussed.The current antitumor strategy of targeting and regulating ERK1/2 was summarized,and the possibility of exploring potential targets was elucidated,thus providing new insights into the developmental research of ERK1/2 as an ideal anticancer target.
