Visualization Analysis of Research Hotspots of Breast Cancer Microenvironment Based on CiteSpace and VOSviewer
10.3971/j.issn.1000-8578.2024.24.0004
- VernacularTitle:基于CiteSpace及VOSviewer的乳腺癌微环境研究热点可视化分析
- Author:
Yuhang FANG
1
,
2
;
Yi XIE
1
,
2
;
Shuhan YANG
1
,
2
;
Suying LIU
3
;
Liyuan FANG
3
;
Yan WANG
3
;
Runxi WANG
3
;
Ying ZHANG
3
Author Information
1. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
2. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.
3. Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Breast cancer microenvironment;
Mechanism exploration;
Cancer treatment;
Visual analysis;
Citespace;
VOSviewer
- From:
Cancer Research on Prevention and Treatment
2024;51(6):448-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the status of knowledge graph-based research into breast cancer microenvironment and to predict future research hotspots. Methods The literature related to breast cancer microenvironment in recent 20 years was retrieved from CNKI and Web of Science Core Collection database and analyzed with CiteSpace and VOSviewer. Results A total of 825 Chinese articles and 16,221 English articles were retrieved. Visual analysis showed that research focus has gradually shifted from cellular research to molecular research and drug innovation. Cancer stem cells, PD-1, PD-L1, immune checkpoint inhibitors, and nanoparticles are the main subjects of interest in research on breast cancer microenvironment, and the United States has the largest number of studies on breast cancer microenvironment, followed by China and Italy. Conclusion Current research mainly focuses on tumor stemness, immunotherapy, and nanodelivery. Owing to deepening research in this field, the targeting of the breast cancer microenvironment for the prevention of tumor development and metastasis and improvement of tumor prognosis has emerged as a new research direction.
