Research progress on small biomolecule formulations for chemical disinfection of root canals
10.12016/j.issn.2096-1456.2024.07.009
- Author:
CHENG Yiting
1
,
2
,
3
,
4
,
5
;
XIA Mengying
1
,
2
,
3
,
4
,
5
;
LEI Lei
1
,
2
,
3
,
4
,
5
;
HU Tao
1
,
2
,
3
,
4
,
5
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Center for Stomatology &
3. National Clinical Research Center for Oral Diseases &
4. Frontier Innovation Center for Dental Medcine Plus &
5. Department of Preventive Stomatology, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
root canal therapy / root canal disinfection / bacterial biofilm / root canal irrigation / intracanal medicaments / small biomolecules / antimicrobial peptides / nanoparticle
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(7):548-554
- CountryChina
- Language:Chinese
-
Abstract:
Successful treatment of endodontic and periapical diseases requires the elimination of bacteria and microbial biofilms from root canals. Currently, the most preferred irrigation method involves the delivery of sodium hypochlorite via the combination of a syringe and ultrasonic activation. Calcium hydroxide is the main choice for intracanal medicament between endodontic appointments and treatment. However, conventional chemical disinfection of root canals is controversial due to drug permeability and drug resistance. New small biomolecule formulations with high penetrability and bioremediatory capacity, including antimicrobial peptides such as M33D and LL-37, antisense RNA ASwalR/ASvicR and nanoparticles such as silver nanoparticles, mesoporous calcium-silicate nanoparticles and chitosan nanoparticles, have effective antibacterial and antibiofilm properties for use in root canal systems and dentinal tubules, thereby promoting the healing of apical lesions. However, the in vivo drug stability, biosafety, and clinical efficacy of small biomolecule formulations need further investigation. Future research will still focus on the improvement and combination of traditional drugs, as new small molecule formulations and ideal disinfectant drugs need to be developed. In the present paper, we reviewed the development of new antibacterial agents and application of small biomolecule formulations for chemical disinfection of infected root canals.
- Full text:2024061810202700578生物小分子制剂在根管化学消毒中的研究进展.pdf
