Association Study between PTPN22 Gene Polymorphism and Myasthenia Gravis
10.19845/j.cnki.zfysjjbzz.2023.0010
- VernacularTitle:PTPN22基因多态性与重症肌无力的相关性
- Author:
Yuan SU
1
;
Yaoxian YUE
1
Author Information
1. Neurorehabilitation center,Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100144,China
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
PTPN22;
Gene polymorphism;
Susceptibility;
Severity
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the susceptibility,severity and generalization of myasthenia gravis (MG) and polymorphisms of rs2488457 and rs3811021. Methods We compare the allele frequencies between 480 MG patients and 487 healthy controls,between each pair of MG subgroups and between each MG subgroup and the control group.Subgroups were specified by susceptibility (gender,onset age,thymoma,AChRAb and onset muscle involvement,and each subgroup within a comprehensive classification of MG),maximal severity and generalization of MG.We compare genotype frequencies under log-additive and codominant mode of inheritance. Results No significant differences were found in allele frequencies of the two SNPs between MG group/each MG subgroup and the control group,and between each pair of MG subgroups,as well as no significant differences in genotype frequencies under additive and codominant mode of inheritance.In the comprehensive classification of MG established with combination of clinical features,there were no significant differences in allele and genotype frequencies of the two SNPs in each subgroup. Conclusion PTPN22 gene polymorphisms are not associated with the susceptibility,severity or generalization of MG.
- Full text:2024061723244378789Association Study between PTPN22 Gene Polymorphism and Myasthenia Gravis.pdf
