Study on changes of blood brain barrier permeability in asymptomatic carotid artery stenosis patients
10.19845/j.cnki.zfysjjbzz.2023.0007
- VernacularTitle:无症状性颈动脉狭窄患者血脑屏障通透性变化的研究
- Author:
Xiaokun YIN
1
;
Beilei CHEN
1
Author Information
1. Department of Neurology,Subei people Hospital,Yangzhou 225001,China
- Publication Type:Journal Article
- Keywords:
Carotid stenosis;
Magnetic resonance imaging;
Blood brain barrier;
Cerebral hypoperfusion;
Brain atrophy
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and correlations of the permeability of blood brain barrier (BBB),the cerebral brain perfusion and the volume of gray matter in patients with asymptomatic carotid artery stenosis (ACAS) by arterial spin labeling (ASL) MRI,dynamic contrast-enhanced (DCE) MRI and artificial intelligence. Methods ASL-MRI,DCE-MRI and three-dimension brain volume (3D-BRAVO) imaging were performed respectively on 40 patients with ACAS,then transferred them to the workstation for image post-processing to obtain cerebral blood perfusion,BBB permeability (which was expressed by volume transport constant Ktrans) and gray matter volume of both side.The above data were statistically analyzed and tested. Results Compared with the contralateral side,the stenosed side had a significant lower cerebral brain perfusion(P<0.001) and higher Ktrans value (P<0.05) in patients with ACAS.The volume of gray matter of the stenosed side was significantly smaller than the contralateral side(P<0.001),there were significant differences between bilateral temporal lobe,frontal lobe,parietal lobe and insular lobe(all P<0.05).Correlation analysis shows there was a negative correlation between Ktrans value and CBF value on the stenosed side (r=-0.334,P<0.05). Conclusion In patients with ACAS,there are lower cerebral brain perfusion and higher BBB permeability in the stenosed side.The increase BBB permeability in the stenosed side in patients with ACAS is related to the decrease in cerebral brain perfusion.
- Full text:2024061723175406750Study on changes of blood brain barrier permeability in asymptomatic carotid artery stenosis patients.pdf
