The relationship between serum CyPA,FGL2 levels,EEG abnormality and cognitive function in patients with epilepsy
10.19845/j.cnki.zfysjjbzz.2023.0034
- VernacularTitle:癫痫患者血清CyPA、FGL2水平、脑电图异常与认知功能的关系
- Author:
Dandan LIU
1
Author Information
1. Department of Neurology,Linfen People Hospital,Linfen 041000,China
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Cyclophilin A;
Fibrinogen like protein 2;
Electroencephalogram;
Cognitive function
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(2):143-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum cyclophilin A (CyPA),fibrinogen like protein 2 (FGL2),electroencephalogram (EEG) abnormality and cognitive function in patients with epilepsy.Methods A total of 116 epileptic patients admitted to our hospital from April 2019 to April 2022 were selected as the study subjects,in addition,116 healthy controls from the same period were selected as controls.Patients were divided into normal EEG group and abnormal EEG group according to EEG results,and the abnormal EEG group was grouped into mild group,moderate group and severe group.Serum FGL2 and CyPA levels were detected,the correlation between serum FGL2,CyPA levels,abnormal degree of EEG and cognitive function were analyzed.Results The levels of serum FGL2 and CyPA in epileptic group at 1 h and 24 h after seizure higher than those in control group (P<0.05);the levels of serum FGL2 and CyPA at 24 hours of seizure lower than those at 1 hour of seizure (P<0.05).The levels of serum FGL2 and CyPA in patients with abnormal seizure for 1 h and 24 h higher than those in normal seizure for 1 h and 24 h (P<0.05).The levels of serum FGL2 and CyPA in the severe group at 1 h and 24 h after seizures higher than those in the moderate and mild groups at 1 h and 24 h after seizures,and those in the moderate group were higher than those in the mild group (P<0.05).The total score and each score of MoCA in epilepsy group lower than those in control group (P<0.05).The levels of serum FGL2,CyPA and abnormal degree of EEG negatively correlated with MoCA score of epileptic patients at 1 h and 24 h after seizures (P<0.05). Conclusion The levels of serum FGL2 and CyPA in epileptic patients are highly expressed,and gradually increase with the aggravation of EEG abnormalities.The levels of serum FGL2,CyPA and EEG abnormality are closely related to the cognitive function of epileptic patients.
- Full text:2024061722574994522The relationship between serum CyPA,FGL2 levels,EEG abnormality and cognitive function in patients with epilepsy.pdf
