Expression and clinical significance of miR-26b and platelet P-selectin (CD62p) in serum of patients with cerebral infarction
10.19845/j.cnki.zfysjjbzz.2023.0030
- VernacularTitle:miR-26b与血小板P选择素(CD62p)在脑梗死患者血清中的表达及临床意义
- Author:
Wenwen PEI
1
;
Wenmin ZHANG
1
Author Information
1. Department of Neurology,Linfen People Hospital,Linfen 041000,China
- Publication Type:Journal Article
- Keywords:
Platelet P-selectin;
MicroRNA-26b;
Cerebral infarction;
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(2):124-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of microRNA (miR)-26b and platelet P-selectin (CD62p) in serum of patients with acute cerebral infarction.Methods A total of 128 patients with acute cerebral infarction (case group) and 128 healthy people with physical examination results (health group) were selected as the research objects.The relationship between the expression levels of serum miR-26b and CD62p and the clinicopathological parameters of the patients in the case group as well as their predictive power for poor prognosis 3 months after the onset were analyzed.Results The expression level of miR-26b in the case group was significantly lower than in the healthy group,and the expression level of CD62p was higher than that in the healthy group (P<0.05).There were significant differences in the expression levels of serum miR-26b and CD62p between patients with different degrees of neurological deficit,cerebral infarction volume and prognosis (P<0.05).Serum miR-26b in the case group was negatively correlated with mRS score,cerebral infarction volume and NIHSS score,while CD62p was positively correlated with mRS score,cerebral infarction volume and NIHSS score (P<0.05).Increased NIHSS score and cerebral infarction volume,low expression of miR-26b and high expression of CD62p were risk factors for poor prognosis in patients with acute cerebral infarction (P<0.05).The ROC curve showed that the area under the curve of serum miR-26b combined with CD62p in predicting poor prognosis of acute cerebral infarction was 0.950. Conclusion Serum miR-26b and CD62p are related to infarct volume,degree of neurological deficit and 3-month prognosis in patients with acute cerebral infarction,which are helpful for early prediction of clinical prognosis.
- Full text:2024061722452450932Expression and clinical significance of miR-26b and platelet P-selectin CD62p) in serum of patients with cerebral infarction.pdf
