The relationship between serum β2-microglobulin and cystatin-C levels and post-stroke depression in patients with acute cerebral infarction
10.19845/j.cnki.zfysjjbzz.2023.0065
- VernacularTitle:急性脑梗死患者早期血清中β2-微球蛋白和胱抑素-C水平与卒中后抑郁的关系
- Author:
Yuqing TIAN
1
;
Lianqiu MIN
1
Author Information
1. The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Post-stroke depression;
β2-microglobulin;
Cystatin-C
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between early serum β2-microglobulin (β2-MG) and cystatin-C (Cys-C) levels and post-stroke depression (PSD) in patients with acute cerebral infarction and their clinical significance. Methods Patients with acute cerebral infarction within 72 hours of the first onset were consecutively collected,and the diagnosis met the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018,all confirmed by head MRI DWI,with reference to the diagnostic criteria of PSD and the 24-item version of the Hamilton Depression Scale-24 (HAMD-24) scores were included in the patients. Scores≥8 were included in the study group (PSD group),and the PSD group was further divided into two subgroups,mild and moderate-severe,according to the HAMD score. Laboratory indicators such as serum β2-MG,Cys-C and biochemistry and clinical data were collected on admission. Results 64 of 174 patients with acute cerebral infarction were diagnosed with PSD,with an incidence of 37%. Compared with the control group,there were statistical differences in age,hypertension,high-density lipoprotein cholesterol (HDL-C),serum creatinine (Scr),β2-MG and Cys-C in the study group,and the results of multifactorial logistic regression analysis showed that age,β2-MG and Cys-C might be the most important factors. β2-MG and Cys-C may be independent risk factors for the occurrence of PSD;meanwhile,the levels of β2-MG and Cys-C were found to be positively correlated with the severity of PSD (P<0.01). The analysis of the role of serum β2-MG and Cys-C in the diagnosis of PSD by applying ROC curves showed that the AUC of β2-MG was 0.781,with a sensitivity of 0.672 and specificity of 0.909;the AUC of Cys-C was 0.785,with a sensitivity of 0.828 and specificity of 0.736;the AUC of the combined diagnosis was 0.815,with a sensitivity of 0.656 and specificity of 0.909.Conclusion Age,serum β2-MG and Cys-C may be independent risk factors for the occurrence of PSD,and serum β2-MG and Cys-C are associated with the severity of PSD;β2-MG and Cys-C may have some diagnostic value for the occurrence of PSD,and the combined diagnostic value of the two is higher.
- Full text:2024061722230640782The relationship between serum β2-microglobulin and cystatin-C levels and post-stroke depression in patients with acute cerebral infarction.pdf
