Association between serum inflammatory cytokines and Parkinson disease with pain
- VernacularTitle:血清炎症因子水平与帕金森病伴疼痛的相关性研究
- Author:
Qiuyue SHAO
1
;
Kun ZAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson disease; Inflammatory cytokine; Pain
- From: Journal of Apoplexy and Nervous Diseases 2023;40(4):304-309
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between serum inflammatory cytokines levels and Parkinson disease (PD) with pain. Methods A total of 90 PD patients and 88 healthy controls were selected. Serum inflammatory cytokines were detected by multiplex microsphere flow immunofluorescence luminescence assay. Motor symptoms (UPDRS-Ⅲ),stages of disease (H-Y stage) and pain symptoms (KPPS score) were assessed. The relationship between inflammatory cytokines and PD with pain and the diagnostic value of serum IL-1β for PD with pain were analyzed. Results Compared to the HC group,the levels of serum IL-1β,IL-6 and IL-17 were significantly higher in the PD group (P<0.01). Serum IL-1β levels were higher in the PD with pain group than in the PD without pain group (P<0.001). Serum IL-1β levels in PD patients were positively correlated with KPPS scores (r=0.371,P<0.001). Binary logistic regression analysis showed that higher serum IL-1β level was a risk factor for PD with pain (P=0.001). The ROC curve showed that the area under the curve for serum IL-1β diagnosis of PD with pain was 0.741.Conclusion Serum IL-1β level in PD patients is associated with pain symptoms and may be a biological marker for the diagnosis of PD with pain.
- Full text:2024061719273782185Association between serum inflammatory cytokines and Parkinson disease with pain.pdf
