Literature Review of Using Bisphosphonates in the Treatment of Calciphylaxis
10.12376/j.issn.2097-0501.2024.02.009
- VernacularTitle:双膦酸盐类药物用于钙化防御治疗的文献分析
- Author:
Chunsu LIANG
1
;
Shaohong WANG
;
Yizhou ZHANG
;
Xin LIU
;
Ziran NIU
;
Yili SHI
;
Bo ZHANG
Author Information
1. 中国医学科学院北京协和医院药剂科,北京 100730
- Keywords:
calciphylaxis;
bisphosphonates;
pamidronate;
alendronate;
zoledronic acid
- From:
JOURNAL OF RARE DISEASES
2024;3(2):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effectiveness and safety of bisphosphonates in the treatment of pa-tients with calcification defense.Methods PubMed,Embase databases,CNKI and Wanfang were searched to collect the case reports and clinical studies of bisphosphonates for calcification defense.Then,the relevant infor-mation of patients was extracted for statistical analysis.Results A total of 18 case reports were selected involving 20 patients.Thirteen patients(65.0％)were treated with pamidronate,four(20.0％)were treated with etidr-onate,two(10.0％)were treated with alendronate,and one(5.0％)was treated with zoledronic acid.Thirteen patients(65.0％)recovered completely,the recovery time of whom ranged from half month to nine months.The tolerance of bisphosphonates in most patients(90.0％)was good,while one patient who did not tolerate pamidr-onate recovered after the frequency of administration was adjusted and one patient with high dosage of etidronate returned to normal after the discontinuation of the usage.Conclusions Bisphosphonates,an inhibitor of bone resorption,is effective and safe in the treatment of patients with calcification defense.
