Advances in the Diagnosis and Treatment of Cushing's Syndrome
10.12376/j.issn.2097-0501.2024.02.006
- VernacularTitle:库欣综合征的诊疗进展
- Author:
Cen LIU
1
,
2
;
Zinan ZHAO
;
Di CHEN
;
Xin HU
Author Information
1. 北京医院药学部 国家老年医学中心 中国医学科学院老年医学研究院 北京市药物临床风险与个体化应用评价重点实验室(北京医院)
2. 国家卫健委老年医学重点实验室,北京 100730
- Keywords:
Cushing's syndrome;
diagnosis;
individualized treatment;
orphan drugs;
osilodrostat;
pasireotide;
mifepristone
- From:
JOURNAL OF RARE DISEASES
2024;3(2):187-194
- CountryChina
- Language:Chinese
-
Abstract:
Cushing's syndrome(CS),an endocrine disorder resulting from excessive glucocorticoid se-cretion by the adrenal cortex,poses significant challenges to both diagnosis and treatment.The diagnostic process involves comprehensive evaluation,combining laboratory tests and imaging studies for screening,quali-fication,and localization.Surgical intervention remains the primary treatment approach,although pharmacologi-cal therapy also plays a crucial role.With an increasing understanding of the pathogenesis of CS,more potential targets for orphan drug development have been discovered.This article summarizes the current status of diagnosis and treatment for CS and provides an outlook on future research directions.