Association between statins and cerebral microbleeds:A meta-analysis
10.19845/j.cnki.zfysjjbzz.2023.0101
- VernacularTitle:他汀类药物与脑微出血相关性的Meta分析
- Author:
Wenxuan SHANG
1
;
Litao LI
1
Author Information
1. Graduate School of Hebei North University,Zhangjiakou 075000,China
- Publication Type:Journal Article
- Keywords:
Atorvastatin calcium;
Cerebral microbleeds
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(5):431-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective Currently recognized statins are associated with the increased risk of spontaneous intracerebral hemorrhage,but there are still controversies over their association with cerebral microbleeds(CMBs). This meta-analysis systematically evaluates the association between the use of statins and CMBs. Methods CNKI,Wanfang Data,VIP,CBM,PubMed,EMBASE,The Cochrane Library,and Clinical Trials databases were searched for randomized controlled trials(RCTs) of statins and CMBs published from January 1,2016 to October 12,2022. The Cochrane Collaboration's tool for assessing risk of bias was used,Revman 5.3 software was used to assess the methodological quality of RCTs included in this study,and Stata 15.0 software was used for statistical analysis. Results A total of 7 articles involving 656 patients were included in this study. The meta-analysis showed that compared with the control group,there was a significant reduction in the number of CMBs or even disappearance of such lesions after adjuvant therapy with atorvastatin calcium adjuvant therapy(odds ratio=2.41,95% confidence interval:1.78-3.25). Conclusion Existing results show that for patients with ischemic stroke and CMBs,atorvastatin calcium in addition to basic treatment can downregulate blood lipid levels,significantly reduce the number of CMBs,and alleviate the degree of CMBs.
- Full text:2024061710400699611Association between statins and cerebral microbleeds_A meta-analysis.pdf
