Relationship between serum TC,TG,and ox-LDL levels and vulnerable carotid plaque in patients with acute non-cardiogenic cerebral infarction
10.19845/j.cnki.zfysjjbzz.2023.0100
- VernacularTitle:血清TC、TG及ox-LDL水平与急性非心源性脑梗死患者颈动脉易损斑块的相关性
- Author:
Chunjing YANG
1
;
Wei WANG
1
Author Information
1. Department of Neurology,Hebei Yanda Hospital,Langfang 065201,China
- Publication Type:Journal Article
- Keywords:
Acute non-cardiogenic cerebral infarction;
Vulnerable plaques;
Cholesterol;
Triglycerides;
Oxidized low-density lipoprotein
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(5):426-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum total cholesterol(TC),triglyceride(TG),and oxidized low-density lipoprotein(ox-LDL) levels and vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction. Methods According to the stability of carotid plaques,103 patients with acute non-cardiogenic cerebral infarction were divided into stable group(n=61) and vulnerable group(n=42). The basic data and laboratory indicators of the two groups were compared. A multivariable logistic regression analysis was used to determine risk factors for the formation of vulnerable carotid artery plaques. Results Compared with the stable group,the vulnerable group showed significantly higher proportions of diabetes mellitus,hypertension,and hyperlipidemia,significantly higher levels of serum TC,TG,ox-LDL,and low-density lipoprotein cholesterol(LDL-C),and a significantly lower level of serum high-density lipoprotein cholesterol(HDL-C)(all P<0.05). The receiver operating characteristic curve analysis revealed that serum TC,TG,LDL-C,HDL-C,and ox-LDL could all be used to predict the formation of vulnerable carotid plaques in patients with acute non-cardiac cerebral infarction(all P<0.05). The multivariable logistic regression analysis demonstrated that diabetes mellitus,hypertension,hyperlipidemia,TC≥5.455 mmol/L,TG≥1.305 mmol/L,LDL-C≥2.655 mmol/L,HDL-C≤1.230 mmol/L,and ox-LDL≥457.765 μg/L were risk factors for vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction(all P<0.05). Conclusion Various factors can drive the formation of vulnerable carotid plaques in patients with acute non-cardiogenic cerebral infarction. TC,TG,and ox-LDL are closely related to vulnerable plaque formation.
- Full text:2024061710364453419Relationship between serum TC,TG,and ox-LDL levels and vulnerable carotid plaque in patients with acute non-cardiogenic cerebral infarction.pdf
