Effect of endovascular therapy on cognitive function in patients with moderate or severe vertebrobasilar artery stenosis
10.19845/j.cnki.zfysjjbzz.2023.0094
- VernacularTitle:血管内治疗对椎基底动脉中重度狭窄患者认知功能的影响
- Author:
Yuanqing WANG
1
;
Lihua DONG
1
Author Information
1. Department of Neurology,People Hospital of Rizhao,Rizhao 276800,China
- Publication Type:Journal Article
- Keywords:
Basilar artery stenosis;
Cognitive dysfunction;
Endovascular stenting;
Neuropsychological tests
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(5):397-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of endovascular therapy for cognitive dysfunction in patients with moderate or severe vertebrobasilar artery stenosis. Methods A total of 78 patients with cognitive dysfunction due to basilar artery stenosis who were treated in the Outpatient and Inpatient Department of Neurology,People's Hospital of Rizhao,China from March 2019 to November 2022 were prospectively enrolled and divided into endovascular stenting(EVS) group and non-EVS group according to whether they underwent endovascular therapy. Before and after treatment,attention and processing speed-trail making test(TMT)-A,executive function-TMT-B,and mini-mental state examination(MMSE) were conducted. These neuropsychological tests were carried out again after 6 months of follow-up. Computed tomography perfusion examination was performed twice before and after treatment to evaluate the patients' cerebral blood perfusion. The clinical data of the two groups were compared to summarize the therapeutic effect on cognitive dysfunction. Results A total of 78 patients,aged(45.03±13.00)years,with a male-to-female ratio of 1.79∶1,were included in the study. There were no significant differences between the EVS group and the non-EVS group in age,sex,years of education,hypertension,diabetes,stroke history,smoking history,and drinking history(P>0.05). Within one week after treatment,MMSE improvement was significantly different between the EVS group and the non-EVS group(P<0.001). There were no significant differences in the changes in TMT-A and TMT-B between the two groups(P>0.05). After 6 months of follow-up,the improvements in MMSE,TMT-A,and TMT-B in the EVS group were better than those in the non-EVS group(P<0.05). In the EVS group,cerebral blood perfusion was significantly improved,the time to peak was significantly shortened,and the cerebral blood flow was increased. No similar changes were observed in the non-EVS group. Conclusion Endovascular stenting for vertebrobasilar artery stenosis has a certain clinical value in improving cognitive function,and the effect becomes more obvious with the extension of time.
- Full text:2024061709385116655Effect of endovascular therapy on cognitive function in patients with moderate or severe vertebrobasilar artery stenosis.pdf
