Clinical characteristics of cognitive impairment in patients with Parkinson disease with or without neurogenic orthostatic hypotension
10.19845/j.cnki.zfysjjbzz.2023.0125
- VernacularTitle:伴或不伴神经源性直立性低血压的帕金森病患者认知损害的临床特点
- Author:
Xiaofan XUE
1
Author Information
1. Department of Neurology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100043,China
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Orthostatic hypotension;
Cognitive impairment
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(6):530-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective Orthostatic hypotension(OH),a result of autonomic dysfunction,is an important risk factor for cognitive impairment in patients with Parkinson disease(PD). However,the direct relationship between cognitive levels and neurogenic OH in patients with PD remains unclear. We aimed to investigate the relationship between cognitive dysfunction and neurogenic OH in patients with PD,and compare the scores of various cognitive domains between patients with PD with asymptomatic OH and those with symptomatic OH. Methods We retrospectively included 79 patients with PD in the Department of Neurology,Xuanwu Hospital,Capital Medical University,including 19 with symptomatic OH,20 with asymptomatic OH,and 40 without OH. All the patients were examined for the presence or absence of OH by beat-to-beat blood pressure monitoring and the active stand test. The OH questionnaire was used to distinguish between symptomatic and asymptomatic OH. Cognitive function was assessed using a global neuropsychological scale. We used one-way analysis of variance and the Kruskal-Wallis test to determine the association between OH and cognitive dysfunction as well as the characteristics of different cognitive domains in different types of patients. Results There was a positive correlation between the years of education and the levels of cognitive function in all PD groups. Patients with symptomatic OH were more likely to develop poor delayed verbal recall at an earlier stage. Patients without OH had impairment in visual space/executive function more frequently. Conclusion Our findings provide new insights into PD with cognitive impairment that patients with symptomatic OH may be more prone to memory impairment due to the underlying pathophysiological mechanism of OH.
- Full text:202406161556578041Clinical characteristics of cognitive impairment in patients with Parkinson disease with or without neurogenic orthostatic hypotension.pdf
