Clinical and neuroimaging features of adults with myelin oligodendrocyte glycoprotein antibody-associated disease at first attack
10.19845/j.cnki.zfysjjbzz.2023.0151
- VernacularTitle:成人MOG抗体病首次发作的临床和影像学特征分析
- Author:
Wen JIAN
1
;
Yaoyao SHEN
1
Author Information
1. Department of Neurology,Xinyu People Hospital,Xinyu 338000,China
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica spectrum disorder;
Myelin oligodendrocyte glycoprotein;
Acute disseminated encephalomyelitis
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(7):659-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and neuroimaging features of adults with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease at the first attack. Methods We retrospectively analyzed the clinical manifestations,radiological features,laboratory findings,and outcome of 14 adult patients with MOG antibody-associated disease at the first attack who were hospitalized in the departments of neurology of Jiangxi Provincial People's Hospital and Xinyu People's Hospital from January 2018 to January 2022. Results The 14 patients included six males and eight females,with a median age of 29.5 years. The most common initial symptoms were fever and headache (n=5),seizure (n=3),and dizziness (n=3). The supratentorial lesions were located in the thalamus (n=7),subcortical white matter (n=6),cortex (n=5),corpus callosum (n=2), and basal ganglia (n=2). The infratentorial lesions were frequently located in the brainstem:the pons (n=5),middle cerebellar peduncle (n=3),midbrain (n=2), and medulla (n=2). Three patients had spinal cord involvement,with one case of longitudinally extensive transverse myelitis. Thirteen patients had elevated cerebrospinal fluid cell counts,and seven had elevated cerebrospinal fluid protein levels. The serum MOG antibody titer ranged from 1∶3.2 to 1∶512. All the 14 patients received intravenous pulse glucocorticoid therapy. Only one patient had a relapse with optic neuritis. Conclusion In our study,MOG antibody-associated disease showed a slight female predominance and frequently presented as acute disseminated encephalomyelitis. The supratentorial lesions were often located in the thalamus and subcortical white matter,while the infratentorial lesions were frequently in the pons. Intravenous pulse steroid therapy was effecitve in the acute phase. The majority of the patients had a favorable outcome.
- Full text:2024061614283135016成人MOG抗体病首次发作的临床和影像学特征分析.pdf
