Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome.
10.4046/trd.2014.77.3.136
- Author:
Jung Hoon KIM
1
;
Won Jun SONG
;
Ji Eun JUN
;
Duck Hyun RYU
;
Ji Eun LEE
;
Ho Jung JEONG
;
Suk Hyeon JEONG
;
Hyung Koo KANG
;
Jung Soo KIM
;
Hyun LEE
;
Hae Ri CHON
;
Kyeongman JEON
;
Dohun KIM
;
Jhingook KIM
;
Won Jung KOH
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wjkoh@skku.edu
- Publication Type:Case Report
- Keywords:
Kartagener Syndrome;
Primary Ciliary Dyskinesia;
Bronchiectasis;
Nontuberculous Mycobacteria;
Mycobacterium Infections, Nontuberculous
- MeSH:
Adult;
Bronchiectasis;
Cough;
Female;
Humans;
Kartagener Syndrome*;
Korea;
Lung;
Lung Diseases*;
Mucociliary Clearance;
Mucus;
Mycobacterium Infections, Nontuberculous;
Mycobacterium*;
Nontuberculous Mycobacteria;
Respiratory Tract Infections;
Sinusitis;
Situs Inversus;
Sputum
- From:Tuberculosis and Respiratory Diseases
2014;77(3):136-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient's condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.
