Relationship between white matter fiber tract changes and executive function impairment in patients with Alzheimer's disease
- VernacularTitle:阿尔茨海默病患者脑白质纤维束改变与执行功能损害的关系
- Author:
Mingkun LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Alzheimer's disease; White matter fiber bundle; Executive dysfunction; Risk factor
- From: Journal of Apoplexy and Nervous Diseases 2023;40(7):590-595
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the relationship between changes in white matter fiber tracts and executive function impairment in patients with Alzheimer's disease (AD). Methods A total of 118 patients with AD admitted to our hospital from December 2019 to January 2022 were divided into executive dysfunction group(n=46) and normal executive function group(n=72) based on their executive function. General data and the fractional anisotropy (FA) values of white matter fiber tracts in different brain regions were compared between the two groups. Multivariable logistic regression analysis was performed to determine influencing factors for executive dysfunction in patients with AD. Pearson analysis was used to analyze the correlation between the FA values of white matter fiber bundles in various brain regions and the Behavioral Assessment of the Dysexecutive Syndrome (BADS) score. Spearman analysis was used to analyze the correlation between the FA values of white matter fiber bundles in various brain regions and executive dysfunction. A Bayesian network model was constructed and evaluated for its effectiveness. Results Severe dementia and the volume of white matter lesions (WMLs) were independent risk factors for executive dysfunction in patients with AD(P<0.05). BADS score and the mean FA value of white matter fiber bundles were protective factors against executive dysfunction (P<0.05).The FA value of white matter fiber bundles in each region was significantly positively correlated with BADS score(P<0.05) and significantly negatively correlated with executive dysfunction (P<0.05). For the constructed Bayesian network model,the area under the curve was 0.839 (95% confidence interval [CI]:0.822-0.853,P<0.001), indicating high predictive value. Conclusion The FA value of white matter fiber bundles is an independent protective factor against executive dysfunction in patients with AD,which is significantly negatively correlated with executive dysfunction. Measuring white matter fiber bundle changes may be an objective examination method of executive function decline in patients with AD.
- Full text:2024061611175883623阿尔茨海默病患者脑白质纤维束改变与执行功能损害的关系.pdf
