Association of Klotho with cerebrovascular disease and associated biological mechanisms
- VernacularTitle:Koltho与脑血管疾病的关系及其相关生物学机制
- Author:
Yingjie REN
1
;
Huixue ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Klotho; Cerebrovascular disease; Vascular protection; Oxidative stress; Atherosclerosis
- From: Journal of Apoplexy and Nervous Diseases 2023;40(8):763-768
- CountryChina
- Language:Chinese
- Abstract: Cerebrovascular disease is one of the leading causes of death and disability across the world. Vascular homeostasis and recovery is critical to the body. Klotho is an important endogenous pleiotropic protein involved in a variety of pathophysiological processes,such as aging and calcium and phosphorus metabolism,which is closely associated with vascular disease. Recent clinical studies have demonstrated close links between low Klotho levels and various risk factors for cerebrovascular disease,suggesting that Klotho has the potential of predicting the risk of ischemic and hemorrhagic cerebrovascular diseases and poor prognosis. Basic studies have also shown that Klotho plays a crucial role in the maintenance of vascular homeostasis. Klotho can promote the production of nitric oxide,inhibit the expression of inflammatory factors,and mediate antioxidant and anti-aging effects,which can delay atherosclerosis and vascular calcification. Therefore,Klotho may serve as a new target for the prevention and treatment of cerebrovascular disease. This review provides an overview of the relationship between Klotho and cerebrovascular disease and its potential biological mechanisms.
- Full text:2024061611035509170Koltho与脑血管疾病的关系及其相关生物学机制.pdf
