Relationship between platelet-to-lymphocyte ratio and early neurological deterioration in patients with acute ischemic stroke
10.19845/j.cnki.zfysjjbzz.2023.0166
- VernacularTitle:急性缺血性脑卒中患者血小板和淋巴细胞比值与早期神经功能恶化的相关性分析
- Author:
Ruinan MA
1
;
Yunhua YUE
1
Author Information
1. Department of Neurology,Yangpu Hospital,Tongji University School of Medicine,Shanghai 200090,China
- Publication Type:Journal Article
- Keywords:
Platelet-to-lymphocyte ratio;
Ischemic stroke;
Early neurological deterioration;
Risk factor
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(8):735-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective Platelet-to-lymphocyte ratio(PLR) has been proved to be a new biomarker of inflammation in various diseases. The purpose of this study was to explore the relationship between PLR and early neurological deterioration(END) in patients with acute ischemic stroke(AIS). Methods We retrospectively analyzed the clinical and laboratory data of 1 116 patients with AIS admitted to the Department of Neurology of Shanghai Yangpu District Central Hospital from May 2018 to October 2020.The patients were grouped for analysis according to whether END occurred within 72 hours. They were also grouped by the quartiles of PLR(platelet count divided by lymphocyte count). Univariable and multivariable logistic regression analyses were used to explore independent factors influencing END in patients with AIS. The predictive ability of PLR for the occurrence of END was evaluated by using a receiver operating characteristic(ROC) curve. Results A total of 1 116 patients with AIS were included in the study,with 125 patients(11.2%) in the END group and 991 patients(88.8%) in the non-END group. The univariable analysis showed that PLR in the END group was significantly higher than that in the non-END group(151.68 vs 132.89,P<0.05). The multivariable analysis showed that the risks of END in the PLR Q3 and Q4 groups were 2.172 times[odds ratio(OR)=2.172,95% confidence interval(CI) 1.201-3.929,P=0.01)]and 2.571 times(OR=2.571,95%CI 1.441-4.589,P=0.001) that of the PLR Q1 group. According to the ROC curve,the area under the curve for PLR predicting END was 0.587(95%CI 0.536-0.639,P< 0.001),and the optimal critical value was 119.40,with a sensitivity of 77.6% and a specificity of 39.4%. Conclusion PLR is an independent risk factor for END in patients with AIS. The increase of PLR is associated with a higher risk of END,which demonstrates certain predictive ability of PLR for the occurrence of END.
- Full text:2024061610510063491急性缺血性脑卒中患者血小板和淋巴细胞比值与早期神经功能恶化的相关性分析.pdf
