Research advances in peripheral blood brain cell-derived extracellular vesicles as the biomarker for central nervous system diseases
- VernacularTitle:外周血脑细胞来源细胞外囊泡作为中枢神经系统疾病生物标志物研究进展
- Author:
Gaojia ZHANG
1
;
Zhijun ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Brain cell-derived extracellular vesicles; entral nervous system diseases; Biomarker
- From: Journal of Apoplexy and Nervous Diseases 2023;40(9):771-779
- CountryChina
- Language:Chinese
- Abstract: Brain cell-derived extracellular vesicles （BCDEVs） are a group of double-layer membrane-structured nanovesicles which are released by all neural cells in the central nervous system （CNS） and contain the heterogeneity of the biological molecules of their originating cells， and under the physiological and pathological conditions of the brain， they are becoming the key media for communication and waste management between neurons， glial cells， and connective tissue. Based on the different specific molecular markers on the surface of BCDEVs， researchers have successfully enriched different subtypes of BCDEVs from peripheral blood， including neuron-derived extracellular vesicles， astrocytes-derived extracellular vesicles，oligodendrocyte-derived extracellular vesicles， microglia-derived extracellular vesicles， pericyte-derived extracellular vesicles，and endotheliocyte-derived extracellular vesicles. This article reviews extracellular vesicles， summarizes the different specific molecular markers used to enrich different BCDEVs from peripheral blood， and introduces the application of peripheral blood BCDEVs in CNS diseases，so as to clarify their potential as a biomarker and the challenges they face in achieving this goal.
- Full text:2024061415162639433外周血脑细胞来源细胞外囊泡作为中枢神经系统疾病生物标志物研究进展.pdf
