Angelicae Sinensis Radix in Neurodegenerative Diseases： A Review
10.13422/j.cnki.syfjx.20240336
- VernacularTitle:当归在神经退行性疾病中的研究进展
- Author:
Weining SONG
1
;
Shumin LIU
2
;
Mengying WANG
3
;
Wei TIAN
3
;
Shuxiang ZHANG
2
Author Information
1. Graduate School， Heilongjiang University of Chinese Medicine， Harbin 150040， China
2. Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine， Harbin 150040， China
3. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine， Harbin 150040， China
- Publication Type:Journal Article
- Keywords:
Angelicae Sinensis Radix;
active ingredients;
compound prescriptions;
neurodegenerative diseases;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(14):279-287
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are a group of diseases caused by degeneration and dysfunction of the cells and tissues of the central nervous system， mainly including Alzheimer's disease （AD）， Parkinson's disease （PD）， and epilepsy. A common clinical manifestation of these diseases is cognitive decline. Neurodegenerative diseases are more common in the elderly. As population aging is aggravating， neurodegenerative diseases have aroused increasing concern since they seriously affect human health and quality of life. The pathogenesis of neurodegenerative diseases is complex， mainly related to mitochondrial dysfunction， apoptosis， neurotoxin， neurotransmitter abnormalities， oxidative stress， and inflammation. Although western drugs on the market can attenuate the symptoms of neurodegenerative diseases， they may induce severe adverse reactions and are thus not conducive to long-term use by the patients. The Chinese herbal medicine Angelicae Sinensis Radix was first recorded in the Shennong's Classic of Materia Medica （Shen Nong Ben Cao Jing）. It has the functions of activating blood， tonifying blood， modulating the immune system， regulating menstruation， and relieving pain. This paper summarizes the research progress in the effects of Angelicae Sinensis Radix and the prescriptions containing this medicine on neurodegenerative diseases in recent 10 years， aiming to provide a reference for the future application and research of Angelicae Sinensis Radix in the treatment of neurodegenerative diseases.
