Regulatory Mechanism of Mitochondrial Apoptosis in Gastric Cancer and Intervention of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241591
- VernacularTitle:线粒体凋亡在胃癌中的调控机制及中医药干预研究进展
- Author:
Lulu CHEN
1
;
Yuchan CHEN
1
;
Zhongyang SONG
2
;
Haihong ZHAO
1
;
Maofu ZHANG
1
;
Zhiming ZHANG
3
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730000，China
3. Gansu Provincial Hospital of Chinese Medicine，Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
gastric cancer（GC）;
cell apoptosis;
mitochondria;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(14):259-269
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer （GC） is one of the most common cancers in the world， with hidden symptoms， complex pathogenesis， high morbidity， high mortality， and poor prognosis. As one of the classical apoptosis pathways， mitochondrial apoptosis has been widely described in the apoptosis escape by GC cells. Mitochondrial apoptosis can regulate the proliferation， invasion， and metastasis of GC cells via oxidative stress， cell cycle， mitochondrial membrane potential， mitochondrial translocation and other mechanisms， and it is one of the potential targets of traditional Chinese medicine （TCM） intervention to restore the mitochondrial function in GC. The theory of spleen-mitochondria in correlation explains that spleen deficiency and cancer toxin are the root causes of mitochondrial apoptosis. Accordingly， the TCM treatment should follow the basic principle of invigorating spleen to restore healthy Qi and removing cancer toxin to eliminate the root cause. Mitochondrial apoptosis can be promoted by inhibiting oxidative stress， promoting cell cycle arrest， and reducing mitochondrial membrane potential. This therapy can improve the energy metabolism， restore the mitochondrial structure and function， and prevent the occurrence and development of GC， with mild side effects and low drug resistance. However， the mechanism of mitochondrial apoptosis in GC and the target of TCM intervention in GC have not been systematically reviewed. Therefore， this paper systematically summarized the effects of mitochondrial apoptosis on the occurrence and development of GC and the role of TCM in the treatment of GC by intervening in mitochondrial apoptosis， aiming to provide a theoretical reference for the treatment and further research of GC.
