Treatment of Pulmonary Inflammatory Diseases by Traditional Chinese Medicine Through Regulating Mitochondrial Oxidative Stress： A Review
10.13422/j.cnki.syfjx.20241699
- VernacularTitle:中医药调控线粒体氧化应激治疗肺部炎症性疾病研究进展
- Author:
Mengdi SHI
1
;
Chao WANG
1
;
Yafei YOU
1
;
Lisha LU
1
;
Yang YANG
2
;
Weichao JING
2
;
Lujia LIU
1
;
Youpeng WANG
2
Author Information
1. Graduate School，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150001，China
- Publication Type:Review
- Keywords:
mitochondria;
reactive oxygen species （ROS）;
oxidative stress;
traditional Chinese medicine;
pulmonary inflammatory diseases
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(14):249-258
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis， chronic obstructive pulmonary disease， acute lung injury， asthma， and infectious pneumonia are common pulmonary inflammatory diseases worldwide. There is evidence that mitochondria produce a large amount of reactive oxygen species （ROS） when stimulated by inflammation， leading to oxidative stress that affects the onset and progression of pulmonary inflammatory diseases. With in-depth research， traditional Chinese medicine （TCM） has made significant progress in the treatment of pulmonary inflammatory diseases. An increasing amount of evidence indicates that single TCM and their active components， as well as TCM compound formulas， can improve mitochondrial oxidative stress status through multi-target and multi-pathway mechanisms， thereby effectively treating pulmonary inflammatory diseases. Currently， there is a lack of systematic review and summary of TCM research in this field both domestically and internationally. Therefore， this article aims to summarize and conclude the mechanisms by which TCM regulates mitochondrial oxidative stress to intervene in pulmonary inflammatory diseases， providing a scientific basis for its clinical application and offering new ideas and references for in-depth research on the prevention and treatment of pulmonary inflammatory diseases with TCM.
