Research progress on histone acetylation/methylation in oral diseases
- VernacularTitle:组蛋白乙酰化/甲基化在口腔疾病中的研究进展
- Author:
Yuchuan LUO
1
;
Feifei LI
;
Fanyuan YU
;
Bei YIN
;
Ling YE
Author Information
- Keywords: histone modification; histone methylation; histone demethylation; histone acetylation; histone deacetylation; histone demethylase inhibitors; histone deacetylase inhibitors; dental fluorosis; periodontitis; pulpitis
- From: Journal of Prevention and Treatment for Stomatological Diseases 2024;32(6):463-469
- CountryChina
- Language:Chinese
- Abstract: Histone acetylation and methylation can affect chromatin conformation and regulate a variety of biological activities.Abnormal histone acetylation and methylation modifications are related to the occurrence and development of a variety of oral diseases.Histone acetylation and methylation increase or decrease in an orderly manner to regulate the development of teeth.Fluoride ions can destroy the balance between histone acetylation and methylation,which may be related to the occurrence of dental fluorosis.In addition,histone acetylation and methylation are involved in the regula-tion of oral inflammatory diseases.In the inflammatory microenvironment,the expression of histone acetyltransferase GCN5 decreases,and the expression of Dickkopf 1(DKK1)decreases,activating the Wnt/β-catenin pathway and ulti-mately inhibiting the osteogenic differentiation of periodontal ligament stem cells.Enhancer of zeste homolog 2(EZH2)and H3K27me3 levels were decreased in inflamed dental pulp tissues and cells.EZH2 inhibition inhibited the expres-sion of interleukin(IL)-1b,IL-6 and IL-8 in human dental pulp cells under inflammatory stimulation.Histone acetyla-tion/methylation modifications can interact with multiple signaling pathways to promote the occurrence and development of oral tumors and are related to the high invasiveness of salivary gland tumors.Small molecule drugs targeting histone acetylation and methylation-related enzymes can regulate the level of histone methylation/acetylation and have shown po-tential in the treatment of oral and maxillofacial diseases.For example,the histone deacetylase inhibitor vorinostat can inhibit the secretion of inflammation-related cytokines;it also promotes the maturation of odontoblasts and the formation of dentin-related matrix,demonstrating its potential in pulp preservation.Understanding the role of histone acetylation/methylation modifications in the occurrence and development of oral diseases will help promote research on epigenetic modifications in oral diseases and provide new perspectives for disease diagnosis and treatment.
- Full text:2024061410241591344组蛋白乙酰化_甲基化在口腔疾病中的研究进展.pdf
