Prevalence of non-alcoholic fatty liver disease and associated factors in overweight and obese children in Hohhot
10.16835/j.cnki.1000-9817.2024142
- VernacularTitle:呼和浩特市超重肥胖儿童非酒精性脂肪肝 患病现状及相关因素
- Author:
YU Qiong, LI Jianying, CAO Puli, LIU Dong, ZHANG Jian, LI Ruifeng
1
Author Information
1. Department of Pediatrics, Maternal and Child Health Hospital of Inner Mongolia Autonomous Region, Hohhot (010020) , Inner Mongolia Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
Overweight;
Obesity;
Fatty liver;
Prevalence;
Regression analysis;
Child;
Minority groups
- From:
Chinese Journal of School Health
2024;45(5):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore prevalence and associated factors of nonalcoholic fatty liver disease (NAFLD) in overweight and obese children in Hohhot City, so as to provide the oretical basis for developing health education plans and implementing prevention and treatment of NAFLD in children.
Methods:A total of 156 overweight and obese children was enrolled from 4 primary schools in Hohhot City using cluster sampling method during 28th Aug. 2022 to 5th Mar. 2023. Height and weight were measured and body mass index was calculated, and fasting blood was taken in the early morning for fasting blood glucose, alanine aminotransferase, aspartate aminotransferase. Single factor analysis was conducted using ttest, χ2 test and Fishers exact probability method, while multivariate analysis was conducted using Logistic regression analysis and subject characteristic curves.
Results:The differences in age, waist circumference, hip circumference, fasting glucose, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, uric acid, and triglyceride were statistically significant between the nonNAFLD and the NAFLD group (U/t=1 070.0-2 164.0, P<0.05). Significant differences were observed in aspartate aminotransferase (AST) and uric acid levels (AST OR=1.16, 95%CI=1.04-1.28; uric OR=1.01, 95%CI=1.00-1.01, P<0.05). The area under a receiver operating characteristic were 0.737 for aspartate aminotransferase and 0.665 for uric acid, respectively.
Conclusions:The prevalence of NAFLD is high in overweight/obese children in Hohhot, and both elevated aspartate aminotransferase and hyperuricemia could increase the risk of NAFLD in overweight/obese children. Special attention should be paid to the NAFLD in overweight and obese children. It is recommended to reduce both BMI and uric level in the prevention and treatment of NAFLD to achieve better treatment outcomes.
